PNI Founders 2016

Improving Outcomes for those Afflicted with Neurological Conditions and Disorders

As Hippocrates wrote, “The art is long, life is short”.

Dr. Harvey Cushing, the neurosurgeon who discovered polyglandular syndrome in 1912.

Dr. Harvey Cushing

It has been a long, wondrous road to where we are today. The Pacific Neuroscience Institute stands on the shoulders of those innovative clinicians and neuroscientists of the past, such as Dr. Harvey Cushing whose vision and diligence shaped the neuro-scientific medical community of the present.

Despite advances in medicine, treatment and technology, the challenges remain significant. For example, in the United States, each year, primary brain tumors are diagnosed in approximately 80,000 people annually and another 250,000 are diagnosed with a metastatic brain tumor; stroke is the fifth cause of death and a leading cause of disability; and 60,000 Americans are diagnosed with Parkinson’s disease each year. So the journey is an evolution of treatment aiming for enhanced quality of life and cure or better control of these disorders. It is a continuous road where we constantly learn and gather experience and expertise.

PNI building Exterior View Rendering

PNI new building

Surveying the progress we have made, Dr. Daniel Kelly, founder of the Pacific Neuroscience Institute says, “It is an incredibly exciting time to be in neuroscience.” There is a revolution of sorts in the kinds of advances we are seeing in this field. Along with co-founders Drs. Chester Griffiths, Santosh Kesari and Howard Krauss, Dr. Kelly’s goal has been to create an institute that is, “big enough to make a difference and small enough to stay connected to our patients and our vision,” he says. At PNI, we use leading-edge technologies and individualized treatments in a team-based environment for every patient. Each of our specialists at PNI’s eight centers of excellence strives to provide patients with better, more effective, less invasive treatment approaches that result in superior clinical outcomes and longer, higher quality, disease-free lives.

The Pacific Brain Tumor Center neurosurgeons, neuro-oncologists and radiation oncologists treat a wide spectrum of brain and skull base tumors with minimally invasive keyhole techniques, as well as with stereotactic radiotherapy, novel targeted therapies and clinical trials.

Garni Barkhoudarian, MD, Neurosurgeon

Garni Barkhoudarian, MD

Neurosurgeons, endocrinologists, ENT surgeons and radiation oncologists work together at the Pacific Pituitary Disorders Center to provide comprehensive treatment and care for conditions arising from Pituitary tumors.

Working in collaboration with the Brain Tumor and Pituitary Disorders Centers, ENT surgeons and ophthalmologists at the Pacific Eye, Ear & Skull Base Center perform endonasal endoscopic sinus surgery ffor skull base tumors and pituitary tumors, sinonasal cancers and orbital and periorbital tumors.

Stroke and Aneurysm team

Stroke and Aneurysm team
Achal Achrol, MD, Renee Ovando, RN, BSN, SCRN
Jason Tarpley, MD, PhD and George Teitelbaum, MD

Designated an advanced primary stroke center, the hospital’s Pacific Stroke and Aneurysm Center neurologists, interventional neuro-radiologists and neurosurgeons treat emergency and critical vascular lesions in the brain. They offer leading-edge treatments for all types of neurovascular disorders including stroke, intracerebral hemorrhage, intracranial aneurysms and arteriovenous malformations.

DBS programming

Movement Disorders team
JP Langevin, MD & Melita Petrossian, MD

Patients and families dealing with movement disorders such as Parkinson’s disease, essential tremor and dystonia find strong allies in the fight against their condition with neurology and neurosurgery experts at the Pacific Movement Disorders Center.

Pacific Facial Pain Center specialists provide a personalized and comprehensive approach to achieve proper diagnosis, treatment and long-term management of facial pain syndromes. Minimally invasive surgical approaches such as microvasular decompression surgery, are used to very effectively alleviate facial pain while maximizing quality of life.

At the Pacific Adult Hydrocephalus Center neurosurgeons and neurologists provide personalized, comprehensive care and minimally invasive surgery for patients with adult hydrocephalus and intraventricular tumors and cysts.

Along with our clinical and research partners at Providence Saint John’s Health Center and John Wayne Cancer Institute, and support from the Saint John’s Health Center Foundation, physicians and research scientists work together at the Pacific Neuroscience Research Center to develop real-time therapies for patients with brain tumors while clinical trials extend across all centers of excellence.

Our patients tell us that they appreciate the personalized attention we offer. One of our core values is that each patient receives the intimate care that is necessary for the kinds of severe diseases we treat.

Come along with us on this journey. Pacific Neuroscience Institute – delivering personalized precision care today, while innovating for tomorrow.   |   310-582-7640


Top image: PNI founders Drs. Santosh Kesari, Howard Krauss, Daniel Kelly and Chester Griffiths.


Daniel F. Kelly, MD

Daniel F. Kelly, MD, is the Director of the Pacific Neuroscience Institute in Santa Monica, CA. Considered to be one of the top neurosurgeons in the US, Dr. Kelly is internationally recognized in the field of minimally invasive keyhole surgery for brain, pituitary and skull base tumors. He continues to focus his efforts on advancing innovative treatments for patients, providing fellowship training in minimally invasive neurosurgery, and patient education and support.


Zara Jethani, MS, MBA

Zara Jethani, MS, MBA is the marketing director for the Pacific Neuroscience Institute. Her background is in graphic design, molecular genetics research and healthcare marketing.