Current Clinical Trials

Clinical Trials/ResearchCurrent Clinical Trials

We can help you determine the optimal approach. Our clinical trials & other research efforts are summarized below.

Current Clinical Trials for the Brain Tumor Center


  • Boston Biomedical: A Study of DSP-7888 Dosing Emulsion in Combination With Bevacizumab in Patients With Recurrent or Progressive Glioblastoma (GBM) Following Initial Therapy (NCT03149003)



Primary Brain Cancer

  • AbbVie / RTOG: A Study of ABT-414 in Subjects With Newly Diagnosed Glioblastoma (GBM) With Epidermal Growth Factor Receptor (EGFR) Amplification (NCT02646748)
  • Boehringer Ingelheim: A Phase I Dose Escalation and CNS Pharmacokinetic Study of the ErbB Family Inhibitor Afatinib in Patients with Recurrent or Progressive Brain Cancer (NCT02423525)
  • Medicenna Therapeutics, Inc.: An Open-Label Non-Randomized, Multi-Center Phase-2 Study of Convection-Enhanced Delivery (CED) of MDNA55 in Adults With Recurrent or Progressive Glioblastoma (NCT02858895)
  • Nativis: A Feasibility Study of the Nativis Voyager System in Patients With Recurrent Glioblastoma Multiforme (GBM)(NCT02296580)
  • NovoCure, Ltd.: A Single-Center, Open-Label, Randomized Phase II Study of NovoTTF-200A Alone and Combined With Temozolomide in Patients With Low-Grade Gliomas (NCT02507232)
  • Orbus Therapeutics: A Randomized Phase 3 Open-Label Study To Evaluate the Efficacy and Safety of Eflornithine With Lomustine Compared to Lomustine Alone in Patients With Anaplastic Astrocytoma That Progress/Recur After Irradiation and Adjuvant Temozolomide Chemotherapy (NCT02796261)
  • Triphase MRZ-112: Study of Marizomib With Temozolomide and Radiotherapy in Patients With Newly Diagnosed Brain Cancer (NCT02903069)


Brain Metastasis

  • Boehringer Ingelheim: A Phase I Dose Escalation and CNS Pharmacokinetic Study of the ErbB Family Inhibitor Afatinib in Patients with Recurrent or Progressive Brain Cancer (NCT02423525)
  • Eli Lilly and Company: A Phase 2 Study of Abemaciclib in Patients With Brain Metastases Secondary to Hormone Receptor Positive Breast Cancer, Non-small Cell Lung Cancer, or Melanoma (NCT02308020)
  • Kadmon: Study of Tesevatinib in Subjects With Non-Small Cell Lung Cancer, EGFR Activating Mutation, Prior Treatment With a Tyrosine Kinase Inhibitor, and Brain Metastases or Leptomeningeal Metastases (NCT02616393)


Solid Tumors

  • Incyte Corporation: A Platform Study Exploring the Safety, Tolerability, Effect on the Tumor Microenvironment, and Efficacy of Pembrolizumab + INCB Combinations in Advanced Solid Tumors (NCT02646748)


Quality and Outcomes Research

  • CancerLife: Evaluation of a Mobile Digital Solution for Cancer Care and Research: A Feasibility Study (NCT03094741)
  • Family Caregivers: An Exploratory Study of Caregiver Burden Among Family Caregivers of Cancer Patients (NCT03069105)
FOR PROVIDERS: Clinical Trials Flyers

Details about each trial can be found in these downloadable information sheets.


Boeringer Ingelheim

Boston BioMedical


Eli Lilly

Family Caregiver







For more information, contact the Neuro-oncology Clinical Trials Team at or 310-829-8265.