Clinical Trials Allow Patients
to Try Novel Therapeutics

Clinical trials are research studies that contribute significantly to the advancement of clinical and medical knowledge concerning a disease.

The data that is collected during the course of a trial provides a deeper understanding of how to detect, prevent or treat an illness and depending upon your condition, we may recommend participation in a clinical trial.

A clinical trial protocol differs from standard treatment at a doctor’s office where the goal is to diagnose and treat the disease with established therapies. Instead clinical trials involve the use of new therapies, current treatments used in an innovative way, or new surgical procedures. An Institutional Review Board (IRB) approval is always obtained prior to activating a study weighing the risks and benefits of a study. The IRB ensures that the clinical trial is conducted in accordance with all federal, institutional, and ethical guidelines.


Therapeutic Opportunities for Patients

We strive to provide compassionate and state-of-the-art clinical care for each of our patients. Clinical trials bringing novel therapeutics to patients are conducted through John Wayne Cancer Institute and patients are treated in our clinics at Pacific Neuroscience Institute located at Providence Saint John’s Health Center.

We are able to provide innovative clinical trials for patients including those with primary brain tumors like glioblastoma multiforme, as well as patients with cancers that have metastasized to the brain from primary cancers such as breast, prostate, and melanoma. In addition, studies are available for other areas such as pituitary disorders, stroke, quality of life research for patients & caregivers and other neurological questions.

Please contact our neuro-oncology clinical team for a consultation with a specialist or find out if you are eligible for a clinical trial protocol.


Currently Available Clinical Trials

View our current clinical trials:

Brain Tumor Center

Pituitary Disorders Center

Stroke & Aneurysm Center

Center for Quality and Outcomes Research (CQOR)


Completed Study

nsbri logoNational Space Biomedical Research Institute (NSBRI) (PDF): Validation of a Cephalad Fluid Shift Countermeasure: Selection of Optimal Cuff Design Followed by ICP Measurements During Extended Cuff Application: A Study in Collaboration with the National Space Biomedical Research Institute (NSBRI) and National Aeronautics and Space Administration (NASA) (NCT03097523)

We are currently conducting a feasibility study to determine optimal thigh cuff design using a cephalad fluid shift protocol in patients who have an intraventricular catheter (such as Ommaya reservoir) placed for the delivery of central nervous system chemotherapy or for diagnosing potential elevation of ICP. This study is in collaboration with Dr. Brandon Macias, scientist from NSBRI who is testing a device that will prevent visual impairment and intracranial pressure (VIIP) syndrome in astronauts involved in long duration space flights on the International Space Station. The current study explores a number of physiologic variables that may impact vision changes that have been reported in more than half of American astronauts after long duration space flights.


Clinical Trials Round-Up Blog Series