Treatment & Research In Psychedelics
Treatment & Research In Psychedelics (TRIP) Program
The Pacific Treatment & Research in Psychedelics (TRIP) Program is dedicated to the development of psychedelic-assisted therapies and the scientific exploration of how altered states of consciousness can be harnessed to change behavior and improve brain health and quality of life.
Beginning in June 2020, we offer psychedelic-assisted ketamine treatment for off-label use in caring for patients living with conditions such as depression or chronic pain. An FDA-approved drug for use as an anesthetic at higher doses, we use lower “sub-anesthetic” dose ketamine in a psychedelic-assisted therapy model, where the drug is given within the context of a “set and setting” psychotherapy program. Here ketamine is not a treatment given in isolation, but instead is a tool to assist the therapy program in accessing and addressing the psychological or emotional issues underlying the patient’s problems.
Mission of the Pacific TRIP Program
- To develop safe, effective and FDA-approved psychedelic-assisted therapies for anxiety, depression, addiction, PTSD, and other chronic conditions via clinical trials and research
- To expand the scientific understanding of the neurobiological and psychosocial mechanisms underlying the health benefits of psychedelics and expanded states of consciousness
- To advance the ethical and evidence-based practice of psychedelic and consciousness medicine to ensure psychedelic treatments are accessible to patients in need
Given the enormity of behavioral health issues that remain inadequately treated worldwide and the modest effectiveness of existing treatments such as antidepressants and traditional psychotherapy approaches, there is an urgent need to develop more effective treatments for these conditions.
Early studies of psychedelic-assisted therapies for conditions including depression, alcoholism, smoking cessation, and end of life suffering have demonstrated much larger and durable effects compared to existing therapies suggesting that there is great potential for psychedelic-assisted treatments to revolutionize the treatment of mental health and behavioral disorders.
Our goal at PNI is to become one of the leading US centers for psychedelic-assisted therapies research, clinical trials and ultimately delivery of these eventual FDA-approved therapies. We have assembled a world-class team of clinical investigators and secured a state-of-the-art clinical space for performing psychedelic-assisted therapies.
Phase 2 and 3 clinical trials are still required for FDA-approval of psychedelic-assisted therapies and at Pacific Brain Health Center we will help develop these protocols to fully launch our treatment and research programs.
Psychedelic-assisted therapy is an innovative and groundbreaking approach that has the potential to revolutionize the treatment of behavioral, mental health, and substance use disorders.
Psychedelic-assisted therapy involves administering a psychedelic drug to a patient under clinical supervision with the purpose of triggering an altered state of consciousness or mystical experience.
The potential for mystical experiences to produce rapid, profound, and sustained changes in insight, mood, behavior, and consciousness was recognized and first used by indigenous cultures in shamanic and other healing rituals. Psychedelic-assisted therapies for treating behavioral health disorders was studied extensively and safely in approximately 40,000 patients in North America in the 1950’s and 1960’s.
However, despite clear benefit for many patients, its use faded dramatically in the wake of the counter-culture movement and the Controlled Substances Act in 1970, which scheduled psychedelics as dangerous and illegal drugs. Fortunately, there is a renaissance in psychedelic-assisted therapies that has been quietly gaining momentum since the 1990’s.
Current Psychedelic Research
Today multiple clinical trials are underway testing a variety of psychedelic drugs including psilocybin, the active ingredient of “magic mushrooms,” MDMA (“ecstasy”), and ketamine, for a diverse range of indications including major depression, Post-Traumatic Stress Disorder (PTSD), anxiety disorder, end-of-life and palliative care setting, as well as alcohol, nicotine and other substance use disorders.
Available treatments for depression, anxiety, and substance use disorders involve daily administration of a medication aimed at correction of neurochemical imbalances via action at specific receptors (eg serotonin, dopamine, mu opioid).
In contrast, psychedelic-assisted therapy uses the drug to produce a short-lived but intense subjective experience—the mystical or peak experience—which triggers or elicits an afterglow, accompanied by a subsequent positive change in affect, insight, motivation, cognition, and behavior
Qualities of the mystical experience as described by patients include a sense of unity, a noetic quality, sacredness, positive mood, transcendence of time and space, and ineffability. While the exact mechanism of psychedelic-assisted therapy remains an intense area of study, current thinking based on neuroimaging and clinical studies, suggests that a major mode of action may be a transient, but profound state of ego dissolution largely due to an impact on a cortical brain region referred to as the Default Mode Network (DMN).
One of the most interesting potentials of psychedelic-assisted therapies is that a given compound such as psilocybin may have trans-diagnostic potential, meaning achieving a psilocybin-induced mystical state may lead to profound and sustained improvement across multiple disorders including depression, anxiety and addiction.
Importance of “Set and Setting”
The psychedelic experience is influenced not only by the choice of drug, but also by the set (the patient’s mindset entering the experience) and the setting (the environment and surroundings). In psychedelic-assisted therapy, the drug is given within the context of a “set and setting” psychotherapy program.
Prior to the psychedelic dosing session, patients meet with a team of therapists for several preparatory counseling sessions during which their medical and psychosocial history is reviewed, they are able to develop a rapport with the therapy team, and are educated and prepared for the psychedelic experience.
The psychedelic dosing session is done in a special “trip room” designed to facilitate a safe and therapeutic experience for the patients. For safety reasons, the patient is monitored by two clinicians, typically a man and a woman. Patients lie on a comfortable couch, wear eyeshades, and listen to music through headphones to facilitate a focus on the internal experience.
Afterward, patients complete a series of integration therapy sessions to assist them in harnessing the power of the mystical experience to make concrete and sustained changes in their lives.
- “How to Change Your Mind” by Michael Pollan
- 60 Minutes story about psilocybin use to treat addiction, depression and anxiety
- Download pdf information sheet
For more information about research studies in the TRIP program, please Dr. Keith Heinzerling at 310-582-7611.