Recent PNI Publications

News & EventsRecent PNI Publications

Recent PNI Publications:

PNI Mag Fall 2018

PNI Magazine Hits The Newsstands!

October 2018 - PNI's Fall issue of Brain Matters magazine is now available. Read about the leading-edge medical care and clinical trials happening at Pacific Neuroscience Institute.

To find out more and to support programs at PNI, contact us at 310-829-8424.

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cns Oncology

Drs. Saria and Kesari Publish Metastatic Squamous Cell Carcinoma Case Study

Oct 6, 2017: In a rare case study published in CNS Oncology, skin cancer spreading to the brain was treated with a drug combination that was found to benefit the patient.

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young woman

Dr. Melanie Goldfarb on Survivorship Care Gap for Young Adult Survivors of Thyroid Cancer

Sept 10, 2017: Although thyroid cancer is among the five most common carcinomas diagnosed in adolescents and young adults, Dr. Goldfarb's research shows a disconnect in their follow-up care. Read more about what can be done.

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Expert Review Neurotherapeutics

Dr. Santosh Kesari publishes a GBM review about further understanding of the pathology of glioma: implications for the clinic

July 2017 - Glioma classification and grading has been historically based in morphologic appearance of tumor cells: astrocytomas, oligodendrogliomas, oligoastrocytomas and ependymomas. Recent molecular advances have transformed the field of neuro-oncology, as some molecular markers harbor diagnostic, prognostic and therapeutic implications.

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Cognitive Dysfunction In Cancer Is More Than “Chemobrain”

July 2017: Drs. Marlon Saria and Santosh Kesari's article appears in the new issue of Cancer Connect. It explores the idea of an increasing number of individuals surviving a cancer diagnosis and the common concerns raised by cancer survivors -- cognitive dysfunction, frequently referred to as “chemobrain”.

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Future Medicine Logo

Neurosciences research team explores cancer immuntherapies

June 2017: The clinical success of checkpoint inhibitors has led to a renaissance of interest in cancer immunotherapies. The Kesari lab has published a Special Report in Future Medicine which explores the cellular immunotherapy of cancer and provides an overview and future directions.

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ONS logo

Dr. Marlon Saria publishes family caregiver article in ONS

June 2017: Anxiety and Depression Associated With Burden in Caregivers of Patients With Brain Metastases. Dr. Saria an colleagues publish research confirming the link between mood disorders in caregivers to caregiver burden of patients with brain metastases.

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Dr. Santosh Kesari and colleagues explore attacking Glioblastoma differently

June 2017: This paper in Nature Neuroscience provides a possible explanation for the failure of epidermal growth factor receptor (EGFR) inhibition therapy in Glioblastoma Multiforme (GBM). GBM cells survive by side-stepping EGFR attack and pumping up tumor necrosis factor (TNF) production. Targeting both pathways could aid in GBM treatment.

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Dr. Santosh Kesari identifies potential target for GBM targeting

April 15, 2017: Santosh Kesari, MD, PhD, et al, have published a research study that establishes p65 (an upregulated RNA binding protein, promoting glioma cell migration) as a novel target for therapeutic targeting in GBM.

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JP Langevin Federal Practitioner March 2017

Dr. JP Langevin publishes new Deep Brain Stimulation paper

March 2017: Dr. JP Langevin et al's new paper appears in the March 2017 issue of Federal Practitioner. Deep brain stimulation has been successful in treating Parkinson disease and essential tremor and is now reducing PTSD symptoms in the first patient enrolled in an early-phase safety trial.

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Second cancers deadlier in young patients

Dr. Melanie Goldfarb's paper shows second cancers deadlier in young patients

Dr Melanie Goldfarb, MD, FACS, and colleagues publish new study in JAMA Oncology. An expert endocrine surgeon at Pacific Pituitary Disorders Center, Dr. Goldfarb's research looks into the prognosis of younger patients when cancer hits for the second time.

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Dr. Achrol's Research Reveals Cancer Subtypes Using New Approach

Mar 31, 2017: Genetic analysis of cancer types is a focused way to provide personalized care to patients. Achal Singh Achrol, MD's, research paper recently published in BMC Genomics uncovers a finer sub-typing methodology in several cancers that can further enhance how precisely patients are treated.

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restriction spectrum mapping

Dr. Santosh Kesari Moves GBM Treatment Assessment Forward

March 9, 2017: In his recent paper in American Journal of Neuroradiology, Dr. Santosh Kesari and colleagues investigate whether restriction spectrum imaging, an advanced diffusion imaging model, performed after an operation but before radiation therapy, could improve risk stratification in patients with newly diagnosed glioblastoma.

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Dr. Marlon Saria Publishes Research About The Hidden Morbidity of Cancer

The Hidden Morbidity of Cancer - Burden in Caregivers of Patients with Brain Metastases: Dr. Marlon Saria, Director, Center for Quality Outcomes details research about the need for personalized care for caregivers as well as patients.

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Mechanisms of radiotherapy-associated cognitive disability in patients with brain tumours

Dec 16, 2016: This review by Santosh Kesari, MD, PhD appears in NATURE REVIEWS NEUROLOGY. It presents evidence of acute radiation-triggered CNS inflammation and other early neurological alterations and dysfunction in patients who receive standard high-dose radiation treatment of primary and metastatic brain tumors.

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Caregiver stress

Cognitive dysfunction in patients with brain metastases: influences on caregiver resilience and coping

Dec 5, 2016: Scientist and advanced research nurse, Marlon Garzo Saria, RN, PhD has published a paper in Supportive Care in Cancer. He emphasizes the need for family caregiver support for those who look after patients with advanced cancer.
For more information: 310-829-8265 or

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Santosh Kesari MD PhD Research

New Driver of Aggressive Brain Cancer Discovered

Nov 14, 2016: University of Hawaii Cancer Center researchers and co-investigator Dr. Santosh Kesari MD PHD, have identified an essential driver of tumor cell invasion in glioblastoma. Researchers can create novel targeted therapies potentially reducing deaths from this devastating cancer.

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Deep Brain Stimulation of the Basolateral Amygdala: Targeting Technique and Electrodiagnostic Findings

Aug 10, 2016: Jean-Philippe Langevin, MD, director of restorative neurosurgery at Pacific Movement Disorders Center has published a paper in Brain Sciences. This method paper describes the technique used to perform DBS of the amygdala.

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Mifepristone Accelerates Recovery in Cushing's Patient

June 26, 2016: Endocrinologist Dr. Pejman Cohen has published a Cushing's disease case study in Hindawi. The use of mifepristone enabled a patient who had struggled with low cortisol causing fatigue, body aches, nausea, and poor overall quality of life for over 6 years to rapidly recover.

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Phase 1 trial of vocimagene amiretrorepvec and 5-fluorocytosine for recurrent high-grade glioma

Tag-team attack on glioma

Toca FC (extended-release 5-fluorocytosine) and Toca 511 (vocimagene amiretrorepvec) are an investigational therapeutic combination for glioma, consisting of two parts: a prodrug that is inactive on its own and a modified virus that infects the tumor and delivers an enzyme, which then activates the drug and allows it to kill the glioma cells. Cloughesy et al. tested this therapy in 45 human patients with recurrent or progressive high-grade glioma and discovered that the treatment was well tolerated and improved survival compared to an external control group. In addition, the authors identified a gene signature that correlated with response to the treatment, which may help identify the patients most likely to benefit from this approach.

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Pipeline Embolization Device for Brain Aneurysms: 3 Case Studies

May 2016: George Teitelbaum, MD, director at Pacific Stroke and Aneurysm Center has published a paper about three cases using a flow diversion pipeline embolization device for the treatment of cervical carotid and vertebral dissecting aneurysms. The device was successfully deployed in all three patients without complication and can be considered a viable alternative to stent-graft devices.

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Reconstruction of the denuded nasoseptal flap donor site with a free fascia lata graft: technical note

The nasoseptal flap provides hearty vascularized tissue for the reconstruction of skull base defects subsequent to expanded endonasal approaches; however, it leads to exposure of the cartilage at the septal donor site producing crusting and discomfort while it remucosalizes. Dr. Garni Barkhoudarian et al report an alternative technique to reconstruct the denuded nasal septal donor site by means of a free fascia lata graft.

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Role of Endoscopic Skull Base and Keyhole Surgery for Pituitary and Parasellar Tumors Impacting Vision

Role of Endoscopic Skull Base and Keyhole Surgery for Pituitary and Parasellar Tumors Impacting Vision. Kelly DF, Griffiths CF, Takasumi Y, Rhee J, Barkhoudarian G, Krauss HR. J Neuroophthalmol. 2015 Dec;35(4):335-41. PMID: 26576016

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Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs Temozolomide Alone for Glioblastoma: A Randomized Clinical Trial.

Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs Temozolomide Alone for Glioblastoma: A Randomized Clinical Trial. Stupp R, Taillibert S, Kanner AA, Kesari S, et al. JAMA. 2015 Dec 15;314(23):2535-2543.

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Impact of selective pituitary gland incision or resection on hormonal function after adenoma or cyst resection

Impact of selective pituitary gland incision or resection on hormonal function after adenoma or cyst resection. Barkhoudarian G, Cutler AR, Yost S, Lobo B, Eisenberg A, Kelly DF. Pituitary. 2015 Jun 27. PMID: 26115709

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