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April 17, 2018

All About The New Pacific Neuroscience Institute

by Zara Jethani

Breaking Neuroscience Ground: Daniel F. Kelly M.D. and the Pacific Neuroscience Institute Lead In Comprehensive Treatment Neurological Conditions

Santa Monica’s hip and laid-back community is also home to some very high tech neurological medical experts. Daniel F. Kelly, MD, director of Pacific Neuroscience Institute, is considered to be among the top neurosurgeons in the US, well known for his use of minimally invasive “keyhole” endoscopic brain and pituitary surgical techniques.

Daniel F. Kelly, MD
Daniel F. Kelly, MD

As director of Pacific Neuroscience Institute, Dr. Kelly collaborates with a multidisciplinary team of specialists at PNI, John Wayne Cancer Institute, Providence Saint John’s Health Center, and other Providence Southern California affiliates to ensure patients get customized treatment for their specific condition.

Dr. Kelly came to the Providence Saint John’s Health Center in 2007, following 14 years at UCLA. In practice now for over 23 years Dr. Kelly’s unique blend of surgical expertise and ability to put patients immediately at ease, has earned him Southern California’s SuperDoctors award 11 years in a row, and multiple TopDoctor and Patient’s Choice awards.

In 2015, Dr. Kelly and his three co-founders Drs. Chester F. Griffiths (ENT – Otolaryngology), Santosh Kesari (Neuro-Oncology) and Howard R. Krauss (Neuro-Ophthalmology), established the Pacific Neuroscience Institute which is a multidisciplinary institute devoted to the care of patients with a wide spectrum of neurological and cranial disorders. Doctors at PNI’s Centers of Excellence see and treat local, nationwide and international patients.

PNI Founders 2016
PNI Founders

“PNI’s roots are in the brain tumor and pituitary disorders program which we began at Saint John’s in 2007,” said Dr. Kelly. “Pituitary disorders cover a wide range of diseases with such diverse symptoms, patients often spend years trying to get a correct diagnosis.” Pituitary adenomas are the most common benign tumor occurring in the pituitary gland. This small yet mighty gland regulates a wide array of bodily functions including growth and development, sexual and reproductive functions, body metabolism, stress response and in fact is a key player in cognitive function and overall brain health.

The great majority of symptomatic pituitary adenomas are now removed via the natural corridors of the nostrils with a team surgery approach using a high-definition endoscope as the visualization tool. “The beautiful panoramic endoscopic view allows us to sneak in and out of the midline skull base and brain area without brain retraction and without visible scars on the face or head”, Dr. Kelly said. “We also apply the same endoscopic ‘keyhole’ philosophy of minimally invasive yet maximally effective approaches for both benign brain tumors such as meningiomas, and malignant tumors such as metastatic brain tumors and glioblastomas (GBM). Using surgical navigation, ultrasound and low-profile instrumentation, many patients can have a brain tumor removed through one of several keyhole access points such as via a small eyebrow incision, from behind the ear or using ‘gravity assisted’ procedures to reach the tumor without traversing normal brain,” he added.

PNI began with the Brain Tumor and Pituitary Disorders Centers and rapidly integrated other specialities including centers for eye, ear & skull base, facial pain, adult hydrocephalus, movement disorders, strokes & aneurysms and neuroscience research which spearheads PNI’s clinical trials. Current clinical trials led by neuro-onocologist Dr. Kesari, include a large number of glioblastoma and metastatic brain cancer studies. In addition, recent neurosurgical clinical trials led by neurosurgeon Dr. Achal Singh Achrol have used modified adult stem cells to treat motor deficits due to brain trauma or stroke.

Knowledge and education are a priority at PNI and young doctors, international scholars and interns are trained in a setting that provides both academic and practical neuroscience experience, including a hands-on neuroanatomy dissection laboratory directed by neurosurgeon Dr. Garni Barkhoudarian.

PNI and JWCI physicians and scientists have a long academic track record with many hundreds of peer-reviewed neuroscience and neuro-oncology publications. “We are continually striving to innovate and improve our treatments with the goal of helping patients live longer, while maintaining their quality of life. By publishing our findings, we hopefully will help change the global standard of care,” said Dr. Kelly.

PNI, 2125 Arizona Ave.

On March 19, 2018, PNI opened its newly renovated historic clinic building, a Santa Monica Landmark building. Patients can visit the new clinic located on the corner of 22nd Street and Arizona Avenue, in the center of the Santa Monica community, and just across the street from the Providence Saint John’s E.R. A grand opening event is slated for May.

“We’re excited that Pacific Neuroscience Institute is part of Santa Monica. Long-time residents know the 2125 Arizona building. It’s a beautiful restoration and now again a medical clinic as it was back in the 1950’s. We think patients will appreciate the esthetics as well as the continued high-level of care they receive,” said Dr. Kelly.

For more information about PNI, visit

Original article: Santa Monica Mirror,  April 9, 2018


Zara Jethani, MS, MBA

Zara Jethani, MS, MBA, is the marketing director for the Pacific Neuroscience Institute. Her background is in graphic design, molecular genetics research and healthcare marketing. 

About the Author

Zara Jethani, MS, MBA

Zara Jethani

is the marketing director at Pacific Neuroscience Institute. Her background is in molecular genetics research and healthcare marketing. In addition, she is a graphic designer with more than 20 years experience in the healthcare, education and entertainment industries.

Last updated: October 16th, 2018